Vet offices rarely post medication prices, and it's hard to know whether what you're paying is in the right ballpark. These are approximate retail ranges for the most commonly prescribed pet medications as of early 2026. Prices shift by retailer, your pet's weight, and current promotions — use these as a baseline, not a guarantee.
Heartworm preventatives (dogs)
Monthly, year-round for most of the US. Doses scale with your dog's weight.
| Medication | Type | Monthly cost (medium dog) | |---|---|---| | Heartgard Plus | Oral chewable | $10–$14 | | Iverhart Plus (generic) | Oral chewable | $6–$9 | | Interceptor Plus | Oral chewable | $11–$15 | | Sentinel Spectrum | Oral chewable | $14–$18 |
Flea and tick prevention (dogs)
This is the category with the most options and the widest price variation between retailers.
| Medication | Type | Monthly cost (medium dog) | |---|---|---| | NexGard | Oral chewable | $20–$28 | | Bravecto | Oral chewable (3-month dose) | $15–$20/mo equivalent | | Frontline Plus | Topical | $12–$18 | | Simparica | Oral chewable | $18–$25 | | Generic afoxolaner | Oral chewable | $14–$20 |
Flea and tick prevention (cats)
| Medication | Type | Monthly cost | |---|---|---| | Revolution Plus | Topical | $20–$28 | | Bravecto Plus (cats) | Topical (2-month dose) | $18–$24/mo equivalent | | Frontline Plus (cats) | Topical | $10–$15 |
Joint and pain medications
| Medication | Use | Monthly cost | |---|---|---| | Carprofen (generic Rimadyl) | NSAID pain relief | $25–$45 | | Rimadyl | NSAID pain relief | $50–$90 | | Galliprant | Osteoarthritis pain (dogs) | $60–$90 | | Librela injection | Osteoarthritis pain (dogs) | $75–$110/mo |
Thyroid medications
| Medication | Use | Monthly cost | |---|---|---| | Methimazole (cats) | Hyperthyroidism | $20–$40 | | Levothyroxine (dogs) | Hypothyroidism | $15–$35 | | Soloxine (brand) | Hypothyroidism | $35–$60 |
Anxiety medications
| Medication | Use | Monthly cost | |---|---|---| | Fluoxetine (generic Reconcile) | Generalized anxiety | $15–$30 | | Trazodone | Situational anxiety | $10–$25 | | Sileo (dexmedetomidine) | Noise aversion | $35–$55 per tube |
Paying less across all of these
Three things that work consistently: asking your vet about generics (usually 30–50% cheaper for the same drug), buying from an online pharmacy instead of your vet's office (typically 20–40% less), and buying a 6- or 12-month supply when your pet is on something long-term.
PetSaver lets you search any of these medications to see current prices across major retailers in one place.
Prices are approximate retail ranges as of early 2026. Actual costs vary by retailer, pet weight, and current promotions.